Role of Angiomotin‐like 2 mono‐ubiquitination on YAP inhibition
نویسندگان
چکیده
منابع مشابه
Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition.
LATS1/2 (large tumor suppressor) kinases and the Angiomotin family proteins are potent inhibitors of the YAP (yes-associated protein) oncoprotein, but the underlying molecular mechanism is not fully understood. Here, we report for the first time that USP9X is a deubiquitinase of Angiomotin-like 2 (AMOTL2) and that AMOTL2 mono-ubiquitination is required for YAP inhibition. USP9X knockdown increa...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2015
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.201540809